The minister of health, welfare and sport () is the head of the Ministry of Health, Welfare and Sport and a member of the Cabinet and the Council of Ministers. The incumbent minister is Jan Anthonie Bruijn of the People's Party for Freedom and Democracy (VVD).
Regularly, a state secretary is assigned to the ministry who is tasked with specific portfolios. The current state secretaries are Nicki Pouw-Verweij of the BBB and Judith Tielen of the People's Party for Freedom and Democracy (VVD). Respectively, they have been assigned the portfolios of long-term care and social care and of youth care, preventive care, and sport. In the past, there have also been ministers without portfolio assigned to the ministry.