In 2005, there were 26 This American Life episodes.
- Show description: On the experiences of United States National Guard reservists and Marines in post-invasion Iraq
- Act 1: When Weekend Warriors Work on Weekdays â Ira Glass
- Act 2: Marine Life â Jack Hitt
- Show description: On personal struggles leading to unexpected success or failure
- Act 1: Take My Break, Please â David Segal
- Act 2: What Happens in Baghdad, Stays in Baghdad â Jen Banbury
- Act 3: Oedipus Hex â Shalom Auslander
- Show description: An entire episode of a story about the wrongful murder conviction of Collin Warner. After 21 years in prison, Warner's friends managed to prove Warner's innocence and free him from jail.
- Act 1: Untitled â Anya Bourg
- Act 2: The story of Collin Warner continues
- Act 1: Thinking inside the box â David Wilcox
- Act 2: Where's Walter? â Starlee Kine
- Act 3: Giving up the ghosts â Shalom Auslander
- Act 1: The Karachi kid
- Act 2: Not far from the tree â Amy O'Leary
- Act 3: Because I'm the mommy, that's why
- Act 1: The Minister Meets the Martyr
- Act 2: I Am Curious, Jello â David Segal
- Act 3: Eight Percent of Nothing â Etgar Keret
- Act 1: Untitled â Ira Glass
- Act 2: The Spy Who Loved Everyone â Jorge Just
- Act 3: Invisible Girl â Scott Carrier
- Act 1: Working Class Hero Sandwich â Shirleen Holt
- Act 2: Don't Drive Like My Brother â Jonathan Menjivar
- Act 3: Confessions of a Not-So-Dangerous Mind â Brian Montopoli
- Act 1: Froggy Goes A-Courtin â Gabrielle Galanek
- Act 2: Cat Got Your Tongue â David Sedaris
- Act 3: Romance Languages â Ben Karlin
- Act 1: Make Him Say Uncle â Ira Glass
- Act 2: My Favorite Martian â Paul Tough
- Act 1: The Substance of Things Hoped For
- Act 2: God Said, Huh? â Julia Sweeney
- Act 1: Not Your Parents' Parent Trap â Nazanin Rafsanjani
- Act 2: If By Chance We Meet Again â Ira Glass
- Act 3: French Kiss â Sarah Vowell
- Prologue â Ira Glass on the Lackawanna 6
- Act 1: Petra Bartosiewicz on the arrest and conviction of Hemant Lakhani
- Act 2: continuation of Act 1
- Prologue: Ira Glass and Nancy Updike
- Act 1: Small Thoughts in Big Brains â Alex Blumberg
- Act 2: And Daddy Makes Three â Dan Savage
- Act 3: Sucker MC-Square â Robert Andrew Powell
- Act 4: The Art of Adult Conversation â Alexa Junge
- Act 1: Dewey Decibel System â Alex Blumberg
- Act 2: Goldstein on Goldstein â Jonathan Goldstein
- Act 3: Hearth Shaped Box â Julie Hill
- Act 1: The Double Whammy â Ira Glass
- Act 2: Small Fish, Smaller Pond â Nick Hornby
- Show description: Stories from survivors of Hurricane Katrina.
- Prologue: Ira Glass interviews William Nichelson about the role of state and federal authorities
- Act 1: Middle of Somewhere â Ira Glass interviews Denise Moore, a hurricane survivor
- Music interlude: Memphis Minnie, When the Levee Breaks
- Act 2: Forgotten, But Not Lost â Alex Blumberg interviews Lorrie Beth Slonsky and Debbie Zelinsky about an occurrence at the Pontchartrain Expressway bridge
- Music interlude: Fats Domino, "Walking to New Orleans"
- Act 3: Social Studies Lesson â Alex Blumberg interviews Ashley Nelson
- Ray Charles, Them That Got
- Act 4: Diaspora â Cheryl Wagner
- Act 5: Displaced Persons Camp â Lisa Pollak interviews survivors of Hurricane Charley in Florida
- Show description: Stories from the Houston Astrodome and New Orleans about survivors of Hurricane Katrina.
- Act 1: Let it Snow, Let it Snow, Let it Snow â Jane Feltes
- Act 2: No Place Like Dome â Ira Glass
- Act 3: Land Grab â Lisa Pollak
- Act 4: The Long Way Home â Nick Spitzer
- Act 5: Water Bed â Alex Kotlowitz
- Act 1: Mothers of Invention â Alex Kotlowitz and Amy Drozdowska-McGuire
- Act 2: That Guy â Diane Cook
- Act 3: Mall Rat â John Hodgman
- Act 1: In the Event of An Emergency â Ira Glass
- Act 2: P' Is For Porta-Potty â Sarah Koenig
- Act 3: Friday Night Floodlights â Lisa Pollak
- Act 1: Truth, Damn Truth, and Statistics â Alex Blumberg
- Act 2: Not Just a Number â Ryan Gist
- Act 3: What do we do with these numbers anyway? â Ira Glass
- Air date: November 11, 2005
- Prologue â Ira Glass
- Act 1: One Good Deed â Erin Einhorn
- Act 2: The Things That Money Can Buy â Beau O'Reilly
- Air date: November 18, 2005
- Prologue â Ira Glass
- Act 1: Not Just Tourists, Tourists Who Care â Chris Tenove
- Act 2: Johnny Get Your Mouse â Amy O'Leary
- Act 1: Lab Rugrats â Ira Glass
- Act 2: Dreams of Distant Factories â Rachel Louise Snyder
- Act 3: Adventures at Poo Corner â David Sedaris
- Act 1: Rise â Russell Cobb
- Act 2: Fall
- Act 1: Twas the Morning After â David Rakoff
- Act 2: No Tenenbaum, No Tenenbaum â John Hodgman
- Act 3: My So-Called Jesus â Heather O'Neill
- Act 4: An Animal Farm Christmas â David Sedaris
- Act 5: Christmas at Valley Forge â Sarah Vowell
- Act 6: What Would Joseph Do? â Jonathan Goldstein
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