Lippenhuizen () is a village in the municipality of Opsterland in the east of Friesland, the Netherlands. It had a population of around 1,330 in January 2017.
The village was first mentioned in 1315 as Luppingahusum, and means houses of the Luppinga family. Lippenhuizen developed on a sandy ridge in a heath and moorland region. In 1718, the Opsterlandse Compagnonsvaart was extended to near the church for the excavation of peat.
The Dutch Reformed church dates from 1743. In 1860, a tower was added to the church. Lippenhuizen was home to 1,002 people in 1840.
From 1884 to 1947 Lippenhuizen had a stop on the tram line Heerenveen - Drachten.