Lille OSC (Lille Olympique Sporting Club) is a French women's football club based in Villeneuve-d'Ascq. The club is the female section of Ligue 1 men's club Lille OSC. The club was founded in 2005. Since 2017, they currently play in the Seconde Ligue, the second-highest division of women's football in France.
The club was formally founded in 2005 after an agreement between FF Templemars-Vendeville and Lille OSC. The team played several years in Division 2 Féminine until 2017, when LOSC won the D2 championships and was then promoted to Division 1 Féminine. At the end of their first D1 season, the team achieved 6th place.