Lezzeno (Comasco: ) is a comune (municipality) in the Province of Como in the Italian region Lombardy, located about north of Milan and about northeast of Como. As of 31 December 2004, it had a population of 2,088 and an area of .
Lezzeno borders the following municipalities: Argegno, Bellagio, Colonno, Lenno, Nesso, Ossuccio, Sala Comacina, Tremezzo, Veleso, Zelbio.