Leylan-e Gharbi Rural District () is in the Central District of Leylan County, East Azerbaijan province, Iran. Its capital is the village of Qareh Khezer, whose population at the time of the 2016 National Census was 1,813 people in 565 households.
In 2023, Leylan District was separated from Malekan County in the establishment of Leylan County and renamed the Central District. Leylan-e Gharbi Rural District was created in the same district.