Lewisburg is an unincorporated community located in DeSoto County, Mississippi, United States. Lewisburg is approximately south of Olive Branch and approximately north of Independence along Mississippi Highway 305.
A post office began operation under the name Lewisburg in 1872.
Lewisburg is served by the DeSoto County School District
Lewisburg Primary School serves students from Kindergarten to 1st grade. Lewisburg Elementary School serves students grades 2-3. Lewisburg Intermediate School serves grades 4-5. Lewisburg Middle School serves grades 6-8, and Lewisburg High School serves grades 9-12.