Leslie Run is a long third-order tributary to Bull Creek in Columbiana County, Ohio.
According to the Geographic Names Information System, it has also been known historically as:
Leslie Run rises on the Yellow Creek divide about 1.5 miles northeast of New Waterford, Ohio, and then flows southeast and south to join Bull Creek at Negley, Ohio.
Leslie Run drains of area, receives about 36.94 in/year of precipitation, and is about 47.86% forested.