Lesegno is a comune (municipality) in the Province of Cuneo in the Italian region Piedmont, located about southeast of Turin and about east of Cuneo. As of 31 December 2004, it had a population of 868 and an area of .
Lesegno borders the following municipalities: Castellino Tanaro, Ceva, Mombasiglio, Niella Tanaro, and San Michele Mondovì.
Lesegno's history starts in middle age, when in the 11th century, it was given firstly at the March of Turin, then at Asti's bishop and finally at the close Marquisate of Ceva. In 1525, the plague depopulated the village. In 1531 the emperor Charles V, donated Asti's domain and Marquisate of Ceva to Beatrice of Portugal, Duchess of Savoy, so Lesegno will follow House of Savoy's story.