Lepsimandus or Lepsimandos () was a city of ancient Caria, mentioned by Stephanus of Byzantium. Lepsimandus was located on an island of the same name in the Aegean Sea. Lepsimandus was a polis (city-state) and member of the Delian League. It appears in the Athenian tribute lists and paid an annual tribute of 17 drachmae, 1 obol.
Its site is located on Kalolimnos.