Lepotrema amblyglyphidodonis is a species of lepocreadiid digenean parasitic in the intestine of marine fish. It was described in 2018.
The staghorn damselfish, Amblyglyphidodon curacao, (Perciformes: Pomacentridae), is the type-host of Lepotrema amblyglyphidodonis. Another host is the Barrier Reef anemonefish, Amphipron akyndynos (Pomacentridae). The type-locality is off Heron Island, Great Barrier Reef, Australia.