Lepotrema acanthochromidis is a species of lepocreadiid digenean parasitic in the intestine of marine fish. It was described in 2018.
The spiny chromes, Acanthochromis polyacanthus (Perciformes: Pomacentridae), is the type-host of Lepotrema acanthochromidis. The type-locality is off Heron Island, Great Barrier Reef, Australia, and another locality is off Lizard Island, Great Barrier Reef, Australia.