Leo O'Brien

Leo O'Brien may refer to:

• Leo O'Brien (actor) (1970–2012), American television and film actor
• Leo O'Brien (cricketer) (1907–1997), Australian cricketer
• Leo F. O'Brien (1924-1968), American politician, member of the Illinois House of Representatives
• Leo P. O'Brien (1893–1968), American politician, member of the Wisconsin State Senate
• Leo W. O'Brien (1900–1982), American politician, Representative from New York