LeFlore is an unincorporated community located in Grenada County, Mississippi, United States and part of the Grenada Micropolitan Statistical Area . LeFlore is approximately south of Holcomb, Mississippi and approximately north of Avalon, Mississippi on Mississippi Highway 7.
The community was once home to three general stores, a hotel, and a cotton gin.
Leflore is located on the former Illinois Central Railroad.
A post office operated under the name Leflore from 1887 to 1978.