Larry Brune (born May 4, 1953) is an American former professional football player who was a defensive back in the National Football League (NFL) and Canadian Football League (CFL). He played for the Hamilton Tiger-Cats from 1976 to 1977, the Ottawa Rough Riders from 1977 to 1979 and from 1981 to 1982 and for the Minnesota Vikings in 1980. He played college football for the Rice Owls.