Langhorne Creek wine region is a wine region in South Australia that is located on the plains southeast of the town of Strathalbyn along the lower reaches of the Bremer River and Angas River to Lake Alexandrina. The region received appellation as an Australian Geographical Indication (AGI) in 1998 and as of 2014, has a total planted area of and is represented by at least 24 wineries.
The Langhorne Creek wine region is one of five wine regions forming the Fleurieu zone which is located to the south of Adelaide city centre in South Australia. The Langhorne Creek wine region extends southeast of the town of Strathalbyn along the Bremer River and Angas River to Lake Alexandrina, centred on the town of Langhorne Creek. The term Langhorne Creek was registered as an AGI on 16 October 1998.
As of 2014, the most common plantings in the Langhorne Creek wine region within a total planted area of was reported as being Shiraz () followed by Cabernet Sauvignon (), Chardonnay () and Merlot (). Alternatively, red wine varietals account for of plantings while white wines varietals account for of plantings. The total 2014 vintage is reported as consisting of of crushed red grapes valued at A$32,351,720 and of crushed white grapes valued at A$4,835,751. As of 2014, the region is reported as having 24 wineries.