Ladybrand is a small agricultural town in the Free State province of South Africa, situated 18 km from Maseru, the capital of Lesotho. Ladybrand is one of five towns that forms the Mantsopa Local Municipality. Founded in 1867 following the Basotho Wars, it was named after Lady (Catharina) Brand, the mother of the president of the Orange Free State, Johannes Brand.
The settlement of Ladybrand was created by Voortrekkers to give them control over the territories conquered and captured after the above-mentioned Basotho war.
In 1867, a town was established on the farm Mauershoek. It was named after Sir Christoffel Brand's wife, Catharina Fredrica Brand. On 26 March 1900, during the Second Anglo-Boer War, Ladybrand came under the control of the British. A municipality was created in 1904.