Lactiplantibacillus plantarum PS128 is a specific strain of Lactiplantibacillus plantarum, a bacterium of the genus Lactobacillus .
Lactiplantibacillus plantarum is a diverse species of lactic bacterium found in a wide range of ecological niches including plant substrates, meat, milk, as well as in the gastrointestinal tract of humans. Lactic bacteria are gram-positive, oxygen-tolerant anaerobes that have been used in food fermentation for hundreds of years.
Lactiplantibacillus plantarum is "generally recognized as safe". and included in the "qualified presumption of safety" list of the European Food Safety Authority.
A study on Rett syndrome patients found that probiotic Lactiplantibacillus plantarum PS128 supplementation was safe, well-tolerated, and showed promising improvements in cognitive development and dystonia, suggesting potential as a complementary therapy for Rett syndrome.