Labastide-de-Penne (; ) is a commune in the Tarn-et-Garonne department in the Occitania region in Southern France. As of 2023, the population of the commune was 125.
Labastide-de-Penne is located on the departmental border with Lot, in which it neighbours the communes of Lalbenque, Belfort-du-Quercy and Belmont-Sainte-Foi. In Tarn-et-Garonne, it neighbours Puylaroque.