The second season of the Colombian reality television series La casa de los famosos Colombia premiered on 26 January 2025, with a live move-in on Canal RCN. The show follows a group of celebrities living in a house together while being constantly filmed with no communication with the outside world as they compete to be the last competitor remaining to win the cash grand prize.
The season was announced on 17 June 2024. Carla Giraldo returned as co-host of the series. Cristina Hurtado did not return as co-host and was replaced by Marcelo Cezán. The season concluded on 9 June 2025, after 135 days of competition with Andrés Altafulla being crowned the winner, and Melissa Gate the runner-up.
On April 4, 2025, a housemate exchange with La casa de los famosos USA was announced. Melissa was swapped with Manelyk González from La casa de los famosos: All-Stars on Day 73, and returned to the house on Day 77.