LY-487,379 is a drug used in scientific research that acts as a selective positive allosteric modulator for the metabotropic glutamate receptor group II subtype mGluR<sub>2</sub>. It is used to study the structure and function of this receptor subtype, and LY-487,379 along with various other mGluR<sub>2/3</sub> agonists and positive modulators are being investigated as possible antipsychotic and anxiolytic drugs.