L-694247 is a selective serotonin 5-HT<sub>1B</sub> and 5-HT<sub>1D</sub> full agonist, with similar affinities and activational potencies at these two receptors, about 20- to 25-fold greater affinity for the serotonin 5-HT<sub>1D</sub> receptor over the serotonin 5-HT<sub>1A</sub> receptor, and negligible affinity for the serotonin 5-HT<sub>1E</sub> and 5-HT<sub>1F</sub> receptors.
When L-694247 was injected intraventricularly in dehydrated rats, it inhibited water intake. Pre-treatment with a serotonin 5-HT<sub>1D</sub> antagonist abolished this effect. Administration of L-694,247 to normally hydrated rats had no effect on water intake.
L-694247 is a 5-substituted tryptamine derivative.