Kuhistoni Mastchoh District or Nohiya-i Kuhistoni Mastchoh (), also known as the Gorno-Matchinsky Region () is a district in Sughd Region, Tajikistan. The capital of district is the village of Mehron. The population of the district is 25,400 (January 2020 estimate).
The district has an area of about and is divided administratively into two jamoats. They are as follows: