Kouassi-Kouassikro Department is a department of N'Zi Region in Lacs District, Ivory Coast. In 2021, its population was 30,962 and its seat is the settlement of Kouassi-Kouassikro. The sub-prefectures of the department are Kouassi-Kouassikro and Mékro.
Kouassi-Kouassikro Department was created in 2012 by dividing Bocanda Department.