Koca Mustafa Pasha (; died 1512) was an Ottoman statesman. He was grand vizier of the Ottoman Empire from 1511 to 1512. He was Roman (Rum) and probably not a devà Âirme.
He started his career as kapñcñbaà Âñ, that is "chief doorkeeper" of the Topkapi Palace: in this office he acted also as Master of Ceremonies at receptions of foreign ambassadors. He married a daughter of Sultan Bayezid II, Kamerà Âah Sultan, in 1491 and by her he had a daughter, Hundi Hanñmsultan, and a son, Sultanzade Osman Bey. Appointed grand vizier near the end of the reign of Bayezid II, he was executed in 1512. In Istanbul he let convert into mosques two ancient Byzantine churches, which were both named after him: respectively Koca Mustafa Pasha and Atik Mustafa Pasha Mosque.