Klondike is an unincorporated community in Wabash Township, Tippecanoe County, in the U.S. state of Indiana.
The community is part of the Lafayette, Indiana Metropolitan Statistical Area.
A post office was established at Klondike in 1897, and remained in operation until it was discontinued in 1900. On March 20, 1976 an EF4 tornado touched down in Klondike, with golf ball sized hail.
Klondike is served by the Klondike Branch public library, a branch of the Tippecanoe County Public Library.