Khudsiani () is a surname used by Fereydani Georgians from Iran. It is related to the CaucasianGeorgian surname Khutsishvili, "which may be derived from Khutsesi (priest) and mean son of a priest". Notable people with the surname include:
Ali Khudsiani, Iranian Georgian screenwriter and director
Karim Khudsiani, Iranian Georgian screenwriter, television presenter and actor