Khristianovich Institute of Theoretical and Applied Mechanics of the Siberian Branch of the RAS, ITAM SB RAS () is a research institute in Akademgorodok of Novosibirsk, Russia. It was founded in 1957.
The institute was founded by Sergey Khristianovich in 1957, he also became its first director. In 1957, the institute was located within the territory of SibNIA, where it was engaged in the creation of a supersonic wind tunnel until 1960.
In 1991, the International Center for Aerophysical Research (ICAR) was established at the institute. In 1997, the institute became a member of the International Supersonic Tunnel Association (STAI).
In 2005, the institute was named after Sergey Khristianovich.
As of 2023, three scientists at the institute had been arrested on suspicion of treason of sharing hypersonic technology.
The main directions of scientific research are physical-chemical mechanics, aerogasdynamics, mathematical modeling in mechanics, mechanics of rigid body, deformations, and destructions.