Khorramdeh-e Sharqi () is a village in Eshqabad Rural District of the Central District in Maneh County, North Khorasan province, Iran.
At the time of the 2006 National Census, the village's population was 619 in 148 households, when it was in Atrak Rural District of Maneh District in Maneh and Samalqan County. The following census in 2011 counted 417 people in 121 households. The 2016 census measured the population of the village as 422 people in 127 households.
In 2023, the district was separated from the county in the establishment of Maneh County and renamed the Central District. Khorramdeh-e Sharqi was transferred to Eshqabad Rural District created in the same district.