Khlong Phraya () is a wildlife sanctuary in southern Thailand, at the boundary of Surat Thani and Krabi Provinces.
The wildlife preserve was established on 31 October 1980, originally covering 95 kmò (59,375 rai) of Krabi Province. On 7 May 1993 it was enlarged by 58.6 kmò (36,613 rai) to include parts of Surat Thani Province as well.
It covers an area of 153.6 kmò (95,988 rai) of the districts Plai Phraya, Phrasaeng, and Chai Buri. The terrain is mostly mountainous and covered with dense forests, but also some grassland.
Animals in the area are langurs, muntjac, tapirs and hornbills.