Khlong Khuean (, ) is a district (amphoe) of Chachoengsao province, central Thailand.
Khlong means 'canal' or 'river'. Khuean means 'dam'. Khlong Khuean and the Chachoengsao area are on the banks of Bang Pakong River. Thus, Khlong Khuean means the 'dam on the river'.
The district was created on 31 May 1993 by splitting it from Bang Khla district.
On 15 May 2007, all 81 minor districts were upgraded to full districts. On 24 August the upgrade became official.
Neighboring districts are (from the east clockwise): Bang Khla, Mueang Chachoengsao, and Bang Nam Priao of Chachoengsao Province and Ban Sang of Prachinburi province.
The important water resource is the Bang Pakong River.
Khlong Khuean is divided into five sub-districts (tambons), which are further subdivided into 32 administrative villages (mubans).
There are five sub-district administrative organizations (SAO) in the district: