Khadem Beg Talish (; died 23 August 1514) was a Sufi and military commander of Talysh origin, who served the Safavid order, and later the dynasty established by the order, the Safavid dynasty. Khadem Beg was a retainer of Soltan Ali Safavi and his brother Ismail Mirza, when they were child, and an important advisor to the Shah Ismail I ().
He died in the Battle of Chaldiran.
Khadem Beg served in many of the campaigns of Shah Ismail, especially in one against Arabian Iraq. In 1508, the Shah conquered Baghdad and made him the first Safavid governor of Baghdad and the whole province, an office which included the task of supervising the Holy shrine of Karbala. Before holding governorship of Baghdad, he was Amir-e Divan (later called Divan-beigi) of the Safavid Empire.
He also held the position of ' of the Safavid order from 1498.
Yadegar Ali Sultan Talish, Khadem Beg's grandson, became Khalifat al-Khulafa for a brief time in 1626âÂÂ1627 and succeeded by his son, Badr Khan Sultan Talish.