Mohammad-Karim Khodapanahi (; born 1941) is an Iranian politician. He was the acting foreign minister of Iran between 1980 and 1981.
Khodapanahi served as the acting minister of foreign affairs from 3 August 1980 to 11 March 1981 in the cabinet led by Prime Minister Mohammad-Ali Rajai. He replaced Sadegh Ghotbzadeh in the post. Mohammad-Ali Rajai succeeded Khodapanahi as acting foreign minister.