Karel van der Pluym (1625, Leiden – 1672, Leiden), was a Dutch Golden Age painter.
He was the son of Dominicus van der Pluym (1593-1661) and Cornelia van Suytbroeck (1597-1652), the first cousin of Rembrandt. According to the RKD he was a pupil of Rembrandt. According to the Frick gallery, their "old woman with a book" was purchased by Henry Clay Frick in 1916 as a Rembrandt.