Karamesutlu is a village in the Babaeski District in the Kñrklareli Province in Thracian Turkey. Its population is 345 (2022). It lies on the highway that connects Babaeski to Kñrklareli and further extends to Dereköy, the border crossing with Bulgaria. It is 7 km from Babaeski and 30 km from Kñrklareli. It is also 2 km from the ramp of the Trans-European Motorway, which goes from Ankara (in central Turkey) to Europe.
It lies on a flat landscape where the highest elevation does not exceed 100 m. Agricultural farming is the primary source of income. Sunflower and wheat are the main crops. Cattle is also raised. The à Âeytan ("devil" in Turkish) Stream flows through the land of the village and provides an important source for irrigation.