The Kanuti (Kküoonootnoü in Koyukon) is a tributary of the Koyukuk River in the U.S. state of Alaska. The river begins near the Arctic Circle and flows generally west, passing under the Dalton Highway near Caribou Mountain. After continuing through a relatively flat basin, it enters a deep canyon before meeting the larger river near Allakaket. The Kanuti National Wildlife Refuge covers a large part of the river basin.