Kanthararom (, ) is a district (amphoe) in northeastern Sisaket province, in northeast Thailand.
The district was established in 1897, then named Uthai Si Sa Ket (à ¸Âà ¸¸à ¸Âà ¸±à ¸¢à ¸¨à ¸µà ¸£à ¹Âà ¸©à ¸°à ¹Âà ¸Âà ¸©). It was renamed Kanthararom in 1913. In 1926 the district office was moved to Ban Khambon in tambon Dun.
Neighboring districts are (from the south clockwise): Non Khun, Nam Kliang, Mueang Sisaket, and Yang Chum Noi of Sisaket Province; Khueang Nai, Mueang Ubon Ratchathani, Warin Chamrap, and Samrong.
The district is divided into 16 sub-districts (tambons), which are further subdivided into 169 villages (mubans). Kanthararom is a township (thesaban tambon) which covers parts of tambon Dun. There are a further 16 tambon administrative organizations (TAO).
<small>Missing numbers are tambons which now form Nam Kliang District.</small>