Kaffrine () is the capital town of Kaffrine Region of Senegal.
There are conflicting stories of Kaffrine's founding, either by a Fula man named Ngange Ka, or by the marabout Saloum Suare. There was an early Serer population in the area. Kaffrine became the capital of the historical region of Ndoucoumane, a former province of the Kingdom of Saloum.I
Kaffrine lies in Senegal's Peanut Basin. Peanuts are the second most common crop for the people of Kaffrine, only behind Millet. Both crops are grown by over 90% of farmers in Kaffrine. Maize is the third most popular crop and grown by over 85% of farmers.
Kaffrine will be heavily affected by the changing climate as erratic rainfall will make current farming practices difficult and reduce agricultural production.
Kaffrine has a station on the Dakar-Niger Railway.