KynurenineâÂÂoxoglutarate transaminase 1 is an enzyme that in humans is encoded by the CCBL1 gene. It is one of the KynurenineâÂÂoxoglutarate transaminases.
This gene encodes a cytosolic enzyme which is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism leads to the formation of reactive metabolites which can lead to nephrotoxicity and neurotoxicity.