Jovan Santos-Knox (born July 5, 1994) is an American professional football linebacker for the Winnipeg Blue Bombers of the Canadian Football League (CFL). He played college football at UMass.
Santos-Knox was signed by the Winnipeg Blue Bombers after driving nine hours with his father to a tryout camp which his father had found in Charlotte, North Carolina. He started his rookie season on special teams but by the end of the regular season was a starting linebacker and was being praised by coach Mike O'Shea and media for big plays at big moments of games. After recording 10 tackles and 3 sacks against Toronto on July 27, 2018, Santos-Knox was named the CFL's third star of the week.
Santos-Knox spent the 2019 season with the Edmonton Eskimos where he played in three regular season games. After the CFL canceled the 2020 season due to the COVID-19 pandemic, he chose to opt-out of his contract with the Edmonton Eskimos on August 27, 2020.
On February 6, 2021, it was announced that Santos-Knox had signed with the Hamilton Tiger-Cats.
On February 7, 2023, it was announced that Santos-Knox had signed with the Ottawa Redblacks. He played in three seasons where he recorded 209 total tackles, five sacks, and two interceptions. He was released on January 30, 2026.
It was announced on February 10, 2026, that Santos-Knox had signed a one-year contract with the Winnipeg Blue Bombers.