Josephson is a patronymic surname meaning "son of Joseph". Notable people with the surname include:
- Andy Josephson (born 1964), American lawyer and politician
- Brian David Josephson (born 1940), Welsh physicist
- Duane Josephson (1942âÂÂ1997), American baseball player
- Erland Josephson (1923âÂÂ2012), Swedish actor and author
- Erik Josephson (1864âÂÂ1929), Swedish architect
- Ernst Josephson (1851âÂÂ1906), Swedish painter
- Ian Josephson, Canadian judge
- Julien Josephson (1881âÂÂ1959), American motion picture screenwriter
- Karen Josephson (born 1964), American swimmer
- Les Josephson (1942âÂÂ2020), American football player
- Mark Josephson (1943âÂÂ2017), American cardiac electrophysiologist
- Matthew Josephson (1899âÂÂ1978), American journalist and author
- Samantha Josephson (died 2019), American murder victim
- Sarah Josephson (born 1964), American swimmer
- Timothy Josephson, American politician
- Mark Josephson (entrepreneur) (born 1972), American entrepreneur and Executive coach
See also