John V. Oyler (born 1968) is an American executive. He is known for co-founding BeOne, a biotechnology company, with biochemist Xiaodong Wang.
Oyler grew up in Pittsburgh, Pennsylvania. He attended the Massachusetts Institute of Technology. He graduated with a degree in mechanical engineering in 1990.
Oyler began his career as a consultant at McKinsey & Company, which often involved travel to China. During his time at McKinsey, he earned an MBA degree from Stanford University and continued to work there after graduate school.
Oyler joined Genta, a biotechnology company focused on cancer drugs, in 1997. At Genta, Oyler hired new management and grew the company's valuation from a few million dollars to $1.7 billion.
In 1998, Oyler was a founder of Telephia, a telecom research company where he served as president. Nielsen Holdings acquired Telephia in 2007. Oyler was also headed Galenea, a company focused on treatments for psychiatric diseases, from 2002 to 2004.
In 2005, Oyler returned to China and co-founded BioDuro, a contract research organization. PPD acquired BioDuro in 2009.
Oyler co-founded the company in 2010 with Chinese biochemist Xiaodong Wang, whom Oyler met while working at BioDuro.
The company has developed two cancer medicines, namely Tevimbra, a checkpoint inhibitor, and Brukinsa, a Bruton's tyrosine kinase inhibitor. As of 2025, BeOne has 11,000 employees.
Oyler is married and has one daughter.