John Mdluli (born 14 July 1972) is a liSwati former professional footballer who played as a forward for clubs in South Africa and Israel.
Mdluli was one of the top scorers in 2006 in Eswatini (then Swaziland).
A goal he scored while playing for Hapoel Jerusalem against Maccabi Ironi Kiryat Ata in 2001 was voted for the goal of the decade by Hapoel Jerusalem Supporters.
With the Eswatini national team, Mdluli participated at the 2001 COSAFA Cup.