John Johnston House is a historic home located near Yanceyville, Caswell County, North Carolina. It was built about 1825, and is a two-story, three bay by two bay, hall-and-parlor plan frame dwelling with Federal style architectural details. A one-story rear ell was added in 1990. It was moved to its present location about 1921.
It was added to the National Register of Historic Places in 1997.