John E. Cheatham House is a historic home located at Lexington, Lafayette County, Missouri. It was built about 1868, and is a two-story, Italianate style brick dwelling. It has a low-pitched, metal-covered hipped roof with a bracketed cornice. A one-story kitchen addition was constructed about 1880. Also on the property is the contributing brick root cellar.
It was listed on the National Register of Historic Places in 1993.