John B. and Lydia Edwards House is a historic home located at Oswego in Oswego County, New York. It is a two-story, rectangular frame residence built between 1834 and 1835. Its owner John B. Edwards was abolitionist Gerrit Smith's agent at Oswego and the house is well documented as a way station on the Underground Railroad.
It was listed on the National Register of Historic Places in 2001.