Jessie is a census-designated place in northern Griggs County, North Dakota, United States. As of the 2020 census, Jessie had a population of 22. An unincorporated community, it was designated as part of the U.S. Census Bureau's Participant Statistical Areas Program on March 31, 2010. It was not counted separately during the 2000 Census, but was included in the 2010 Census.
It lies along North Dakota Highway 65 northwest of the city of Cooperstown, the county seat of Griggs County.