is a major highway on the island and prefecture of Hokkaido in northern Japan. The highway begins at an intersection with National Routes 279 and 278 in Hakodate. It travels north across the southern half of the island, traveling through Otaru where it curves to the east toward its endpoint at an intersection with National Route 12 in Chà «à Â-ku, Sapporo.
National Route 5 traces its origin to the , a road designed by Horace Capron, in 1872. Capron was an American advisor to the Hokkaido Development Commission who was paid to assist in the development of Sapporo as a planned city. The Sapporo Hondà  connected Sapporo to Hakodate at the southern end of the Hokkaido where sea connections to the main island of Japan, Honshu, were located. The Sapporo Hondà  was completed in 1877.
On 4 December 1952, the Cabinet of Japan designated the Sapporo Hondà  as First Class National Highway 5. On 1 April 1965, it was reclassified as National Route 5.
The route lies entirely within Hokkaido.