National Route 169 is a national highway of Japan connecting Nara, Nara and Shingà «, Wakayama in Japan, with a total length of 184.6 km (114.71 mi).
National Route 169 was originally designated on 18 May 1953 as a second-class national highway connecting the now dissolved town, Kinomoto, in Mie Prefecture to Yamatotakada, Nara.