James Ruffin (born February 6, 1987) is an American former football defensive end. He played college football at University of Northern Iowa.
Ruffin was signed by the Tampa Bay Buccaneers as an undrafted free agent in 2010. He was released by the Buccaneers on September 4, 2010.
Ruffin signed with the Cincinnati Bengals on October 17, 2010. He was released by the Bengals on September 3, 2011.
Ruffin played with the Spokane Shock from 2012 to 2014. In 2014, Ruffin set the Spokane Shock record for sacks in a season, and is the Shock's career sack leader. Ruffin's play in 2014 earned him the AFL's Defensive Lineman of the Year Award. On November 24, 2014, Ruffin was again assigned to the Shock.
Ruffin was signed by the Tampa Bay Buccaneers on August 5, 2014. Ruffin was waived by the Buccaneers on August 21, 2014.
On November 24, 2014, Ruffin was again assigned to the Shock.
Married November 4, 2017 to Amber Cardinal